Nigeria Experience in Determining that Loiasis Presented No Risk to Ivermectin Treatment for Onchocerciasis

Authors

  • Nwoke, B. E. B. Department of Animal and Environmental Biology; Member, Mectizan Expert Committee, Imo State University, Owerri, Nigeria

DOI:

https://doi.org/10.4314/njpar.v46i1.3

Keywords:

Nigerian, Onchocerciasis-loiasis co-endemicity, RAPLOA, SAEs

Abstract

  Nigeria accounts for approximately 40% of the global onchocerciasis burden,
affecting more than 50 million people. Onchocerciasis constitutes a major social
and public health problem and therefore cannot be taken for granted. The
discovery and free donation of ivermectin (Mectizan®) encouraged Nigeria and
other endemic countries to implement Mass Drug Administration (MDA) in at-
risk population. Unfortunately, reports from some onchocerciasis-endemic
African countries where onchocerciasis is co-endemic with Loa loa indicate that
Severe Adverse Events (SAEs) may occur in patients who have taken ivermectin.
This threatens the success of the onchocerciasis control/elimination programme in
many of these onchocerciasis-endemic African countries where Loa loa is co-
endemic. Nigeria commenced MDA in 1988 in endemic communities of Kwara
and Kaduna States and later expended MDA to nearly all the transmission zones
and tens of millions of people have been treated with ivermectin including areas
presumed to be onchocerciasis-loiasis co-endemic zone. One striking observation
is that there was no evidence of SAEs in Nigeria. Of the 758 SAEs reported to the
Mectizan Donation Program between 1990 and 2014, only one suspicious case
(0.1%) was reported in Nigeria (around Kwara State, a non-loiasis belt). The
international scientific community has continued to ask questions concerning this.
For instance, the WHO Loa loa Expert Committee met in Paris, France, August
28-30, 2024 and wanted to know the Nigerian experience in determining that
loiasis presented no risk to ivermectin treatment for onchocerciasis. In doing so,
the Expert Committee asked the following questions: (a) what are the Rapid
Epidemiological Mapping of Loiasis (RAPLOA) exercises in Nigeria; (b) what is
the more recent data collected on Loa loa microfilaria density that led Nigeria to
determine that MDA for onchocerciasis was safe; (c) do Nigerians think that the
RAPLOA data differed so much from the microfilaria density data?, and (d) did
loiasis endemicity change over time or is the relationship between RAPLOA and
mf density different in Nigeria? As the Chairman of Nigerian Onchocerciasis
Elimination Committee (NOEC), the present work addresses these programmatic
questions.

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Published

2025-04-02

How to Cite

B. E. B., N. (2025). Nigeria Experience in Determining that Loiasis Presented No Risk to Ivermectin Treatment for Onchocerciasis. Nigerian Journal of Parasitology, 46(1), 24–35. https://doi.org/10.4314/njpar.v46i1.3

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