Historical Review of Human African Trypanosomiasis and Specific Need for Surveillance Strengthening in Abraka Delta State, Nigeria
DOI:
https://doi.org/10.4314/njpar.v45i2.13Keywords:
Human African, trypanosomiasis, T. b. gambiense, tsetse fly, Suramin, NECT, fexnidazole, NigeriaAbstract
Human African trypanosomiasis (HAT) or sleeping sickness is a major public health problem, with epidemics occurring during the early part of the 20th century. Control activities of case-finding, treatment, and vector eradication across northern Nigeria with national and international support drastically reduced the prevalence from 14% between 1931 and 1940 to below 1% by 1980. With these
successes, the Nigerian Institute for Trypanosomiasis Research (NITR) became underfunded and stopped regular active surveys. In 1985, a new HAT-endemic Abraka focus in Delta State emerged, and the Institute strengthened its surveillance there and in Benue State. In 1988, all outstations were closed, except for the Sleeping Sickness Reference Diagnostic Centre, Gboko, and Benue State.
To date, only the Abraka focus has reported HAT case (s) to the WHO in 2012 and 2013. From 2014 to 2017, the Foundation for Innovative New Diagnostics (FIND), in collaboration with NITR and Ministries of Health, introduced intensive passive surveillance in 51 health centres in Delta State aimed at accelerating the control of HAT using rapid diagnostic tools (RDTs), LEDfluorescent microscopy, and molecular methods of LAMP provided free of charge by FIND. The results indicated 157 sero-positives out of 10,093 patients with HAT suspicion index screened but failed to confirm any HAT case by microscopy or molecular analysis. Of interest was the case of HAT exported to the United Kingdom from the Abraka area in 2017, suggesting continuing transmission. To achieve the 2030 HAT global elimination goal, surveillance programmes with sufficient diagnostic capacities must be implemented in Abraka, Delta State, Nigeria. This is not only important, but will also help in generating additional data and information useful in validating the future status of HAT in Abraka, Delta State Nigeria.
References
McLetchie, J. L. (1948). The control of sleeping sickness in Nigeria. Transaction of the Royal Society of Tropical Medicine and Hygiene, 41:445-480. https://doi.org/10.1016/s0035-9203(48)90733-0
McLetchie, J. L. (1953). Sleeping sickness activities in Nigeria, 1931-1952. II. West African Medical Journal, 2(3): 138-150.
Lester, H. M. (1939). The results of sleeping sickness work in northern Nigeria. Transaction of Royal Society of Tropical Medicine and Hygiene, 32(5): 615-627. https://doi.org/10.1016/50035-9203(39)90024-6
Lester H. M. (1945). Further progress in the control of sleeping sickness in Nigeria. Transaction of Royal Society of Tropical Medicine and Hygiene, 38:425-444. https://doi.org/10.1016/0035-9203(45)90053-8
Ministry of Health Northern Region Annual Report (1964). Sleeping Sickness activities and Simulium control, pp10 -52.
Duggan, A. J. (1962). A survey of sleeping sickness in Northern Nigeria from the earliest times to the present day. Transactions of The Royal Society of Tropical Medicine and Hygiene, 56, 439-480. DOI:10.1016/0035- 9203(62)90070-6
Foundation for Innovative New Diagnostics (2012). The First rapid diagnostic test to screen for sleeping sickness is launched. Kinshasha, DRC, 6 December FIND. htpps://www.finddx.org > accessed 25th June 2024
World Health Organization (2023). Home/Newsroom/Fact Sheets/Detail/ Trypanosomiasis, human African sleeping sickness. https://www.who.int,Accessed 12 September 2023
Thompson, K. D. B. (1969). The present sleeping sickness situation in the Northern states of Nigeria. Transaction of Royal Society of Tropical Medicine and Hygiene, 72: 27-32
Mulligan, H. W. (1970). The African trypanosomes. George Allen and Unwin Ltd London. Pp 823-904. ISBN:0046140018
Aiyedun, B.A. &Amodu,A.A. (1976). Human sleeping sickness in the Gboko endemic area of Nigeria. Acta Tropica, 33(1):88-95. PMID: 13637
Weir, A. B., Agbowu, J. & Ajayi, N. (1985). Hyperendemic West African trypanosomiasis in a rural hospital setting. Journal of Tropical Medicine and Hygiene, 88(5): 307-311. PMID: 3836307
Edeghere, H., Olise, P. O., & Olatunde, D. S. (1989). Human African trypanosomiasis (Sleeping sickness): New endemic foci in Bendel State, Nigeria. Tropical Medicine and Parasitology, 40(1): 16-20. PMID: 2740725.
Nigerian Institute for Trypanosomiasis Research Annual Report (1980-1983). NITR Epidemiology Department. Sleeping SicknessActivities, pp 50-53.
Franco, J. R., Simarro, P. P., Diarra, A. & Jannin, J. G. (2014). Epidemiology of human African trypanosomiasis. Clinical Epidemiology, 6:257-275.doi: 10:214/CLEPS39728
World Health Organization (2024). The Global Observatory (https://www.who.int/data/gho/data/indicators/indicator-details/GHO/hat-tb-gambiense), accessed June 2024.
Enwezor, F. N. C., Dede, P. M., Ovbagbedia, P. R., Onwumah, U., Mamman, M., Igweh, A. C., Anagbogu, I., Okeowo, P., Arugba, D., Otobo, E. S., Oseji, M. I., Bieler, S. & Ndung’u (2017). Intensive Passive Surveillance for human African trypanosomiasis in Delta State, Nigeria. Abstract 2.21, paper presented at the 34th General Conference of the International Scientific Council for Trypanosomiasis Research and Control (ISCTRC) and 16th PATTEC Coordinators Meeting, Lusaka, Zambia, September. https://osf.jo > jkguw
Luintel, A., Lowe, P., Cooper, A., MacLeod, A., Büscher, P., Brooks, T., & Brown, M. (2017). Case of Nigeria-Acquired Human African Trypanosomiasis in United Kingdom, 2016. Emerging infectious diseases, 23(7), 1225–1227. https://doi.org/10.3201/eid2307.170695
West African Institute for Trypanosomiasis Research (1951). Nature, 167(4249), 542–543. https://doi.org/10.1038/167542a0
Mulligan, H. W. (1955). Recent investigations on trypanosomiasis in British West Africa. Transaction of Royal Society of Tropical Medicine and Hygiene, 49(3):199-223. doi: 10.1016/0035-9203(55)90065-1. PMID: 14396926.
Nash, T. A. (1937). Climate, the vital factor in the Ecology of Glossina. Bulletin of Entomological Research, 28, 75-127. DOI:10.1017/S0007485300038311
MacLennan, K. J. R., & Kirkby, W. W. (1958). The eradication of Glossina morsitans submorsitans Newst. in part of a river flood plain in Northern Nigeria by chemical means. Bulletin of Entomological Research, 49(1):123-131. doi:10.1017/S0007485300053475
Kernaghan, R. J. (1961). Insecticidal control of vectors of human trypanosomiasis in Northern Nigeria. Journal of Tropical Medicine and Hygiene, 64:303–309 https://europepmc.org/article/med/144553.
Jones, G. (1949). The Anchau Rural Development and Settlement Scheme. By T. A. M. Nash, O.B.E., D.Sc. 1948. H.M.S.O., for the Colonial Office. Pp. iv 22. 3s. 6d. Africa, 19(2): 161-163. doi:10.2307/1156522.
Kernaghan, R. J. & Johnston, M. R. L. (1962).Amethod of determining insecticide persistence in tsetse fly control operations. Bulletin of World Health Organization, 26(1): 139-141. https://apps.who.int/iris/handle/10665/267488
Baldry, D. A. T. (1963). An evaluation by bioassay of the persistence of DDT deposits on riverine vegetation in the Northern Guinea Savannah vegetation zone of Nigeria and observations on the factors influencing the availability of deposits to Glossina, palpalis (R.-D.). Bulletin of Entomological Research, 54(3): 497 – 508. https://doi.org/10.1017/S0007485300048975
Riordan, K. (1967). Persistence of Dicophen, B. P., deposits from suspensions and emulsions on bark in the Northern guinea savannah zone of Nigeria: Investigations by chemical means and bioassay. Pest Articles & News Summaries. Section A. Insect Control, 13(2), 156–162. https://doi.org/10.1080/04345546709415216
Enwezor, F. N. C., Mamman, M. & Igweh, A. C. (2019). NITR’s Contributions towards the elimination of Trypanosomiasis and Onchocerciasis in Nigeria. Nigerian Journal of Parasitology, 252-266. DOI:10.4314/njpar.v40i2.23
Aiyedun, B.A., &Amodu,A.A. (1976). Mel B toxicity in human trypanosomiasis in the Gboko endemic area of Nigeria. Acta tropica, 33(1), 96–100. PMID: 13638
Woo P. T. (1971). Evaluation of the haematocrit centrifuge and other techniques for the field diagnosis of human trypanosomiasis and filariasis. Acta tropica, 28(3), 298–303. PMID: 4400769
Magnus, E., Ververt, T. & Van Meirvenne, N. (1978). Card agglutination test with stained Trypanosome (CATT) for the serological diagnosis of T b. gambiense trypanosomiasis Annale Societe Belge Medical tropicaux, 58:169-176. PMID: 747425
Osue, H. O., Lawani, F.A. G., Saddiq, L.,Aderemi,A., Diarra,A., Lejon, V. & Simmaro, P. (2008).Active transmission of Trypanosoma brucei gambiense sleeping sickness in Abraka, Delta State Nigeria. Science World Journal, 3: 11-34. https://www.scienceworld journal.org
Enwezor, F. N. C., Ikenga, M. A., Idris, I. I., Okere, C., & Wuaor, M. A. (2010). A survey of sleeping sickness in parts of Benue State, Nigeria. Nigerian Journal of Parasitology, 31(2): 43-54.doi: 10.4314/njpar.v31i2.69458.
Enwezor, F. N. C. & Ukah, J. C. (2000).Advanced trypanosomiasis in a child: Case report. Nigerian Journal of Parasitology, 21(1): 143-146. https://www.ajol.info/index.php/njpar/article/view/37749
Ngutor, K. S., Idris, L. A., & Oluyinka, O. O. (2015). Silent human Trypanosoma brucei gambiense infections around the old Gboko sleeping sickness focus in Nigeria. Journal of Parasitology Research, 2016(1), 2656121. https://doi.org/10.1155/2016/2656121
Linder,A. K., Legion, V., Chappius, F., Seixas, J., Kazumba, L., Barret, M. P., Mwamba, E., Erphas, O., Aki, E. A., Villanueva, G., Bergman, H., Simarro, P., Kadima, E. A., Priotto, G. & Franco, J. R. (2020). New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice. The Lancet Infectious Diseases, 20(2): E38-E46. doi: 10.1016/S1473-3099(19)30612-7. Enwezor et al: Historical Review of Human African Trypanosomiasis 375
Umeakuana, P. U., Gibson, W., Ezeokonkwo, R. C. &Anene, B. M. (2019). Identification of Trypanosoma brucei gambiense in naturally infected dogs in Nigeria. Parasites & Vectors, 12: 420 https://doi.org/10.1186/s13071-019-3680-8
Nmorsi, O. P. G., Isaac, C., Igbinosa, I. B., Umuokoro, D. O., & Aitaikuru, D. P. (2010). Human African trypanosomiasis in endemic focus of Abraka, Nigeria. Asian Pacific Journal of Tropical Medicine, 3(6): 448- 450. https:/doi.org/10.1016/S1995-7645 (10)60107-1.
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