Antimicrobial Potentials of <i>Sida acuta</i> Leaf Extracts on Some Resistant Bacterial Isolates
DOI:
https://doi.org/10.4314/njpar.v46i2.2Keywords:
MBC, MIC, phytochemicals, Sida acute, antimicrobial resistanceAbstract
The quest for a solution to antimicrobial resistance issues has recently led to a series of research activities, focusing on plant options which are believed to be accessible and cheaper. Sida acuta leaf extracts were assayed in this study. The powdered leaf samples were subjected to extraction using ethanol, n-hexane, and water as solvents. Aphytochemical analysis of the crude extract was performed. In addition, the potency of each extract was tested against six (6) clinical resistant strains of bacteria and their respective minimum inhibitory concentrations (MICs)
and minimum bactericidal concentrations (MBCs). Phytochemical analyses revealed the presence of phenols, saponins, steroids, tannins, flavonoids, and alkaloids. The data obtained from this study were analysed using SPSS version 23. Data are represented as mean ± standard error of the mean (SEM), while the difference between means was evaluated by analysis of variance (ANOVA) at P≤ 0.05. The ethanol extract showed the greatest antibacterial activity against the tested isolates, whereas the n-hexane extract had the lowest. The extracts also had different minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) against the isolates, with some having bactericidal effects
and others having bacteriostatic effects. The results of this study indicate that S. acuta leaf could be an excellent candidate in the search for plant alternatives that will serve as an effective and accessible antibacterial compound.
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