Ginger or Black Pepper Supplements Attenuate Oxidative stress and Renal Damage in Metabolic Syndrome-induced Wistar Rats
https://dx.doi.org/10.4314/njpar.v44i1.15
Keywords:
Black pepper, Ginger, Oxidative stress, Metabolic syndrome, KidneyAbstract
There has been an increasing occurrence of cardio-metabolic risk factors globally due to increasing consumption of fructosesweetened foods and drinks that cause excessive generation of free radicals. This research investigated the inclusion of ginger and black pepper in the diet as an easy and affordable means of managing oxidative stress and kidney damage in metabolic syndrome-induced rats. Fifteen metabolic syndrome-induced rats were divided into three groups and fed on diets supplemented with 2 % inclusions of ginger or black pepper. Serum activities of antioxidant enzymes and some indices of renal functions were determined. Compared with the normal control, there were significantly (p<0.05) lower activities of all the studied antioxidant enzymes (Superoxide dismutase, Glutathione peroxidase, Catalase, and glutathione reductase) in the groups of metabolic syndrome induced-rats fed ginger or black pepper-supplemented diets which had significantly higher activities of these enzymes if compared with the group of metabolic syndrome-induced rats fed standard diets. The serum concentrations of malondialdehyde in all the groups of metabolic syndrome-induced rats fed the spices-supplemented diets did not significantly (p>0.05) differ from the concentration in the control group. The groups of metabolic-syndrome-induced rats fed ginger or black pepper-supplemented diets had significantly (p<0.05) higher concentrations of urea, uric acid, and creatinine in comparison with the normal control, but significantly (p<0.05) lower concentrations of these metabolites if compared with the metabolic syndrome-induced rats fed a standard diet. Similarly, the concentrations of serum electrolytes were significantly higher (p<0.05) in the groups of metabolic-syndrome-induced rats fed spices-supplemented diets
compared with the normal control. From the findings, it is concluded that including ginger or black pepper in diets could be useful in managing oxidative stress and kidney dysfunction resulting from the consumption of metabolic syndrome-causing
diets.
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