Evaluation of the Antiplasmodial activity of <i>Curcuma longa</i> (turmeric - Zingiberaceae) on <i>Plasmodium berghei</i> in Laboratory Mice.


  • A. Dawet Department of Zoology, Faculty of Natural Sciences, University of Jos, Nigeria.
  • C. H. Golnaan Department of Health Management Technology, Plateau State College of Agriculture, Garkawa, PMB 001, Garkawa, Plateau State, Nigeria.
  • K. Yusuf Department of Zoology, Faculty of Natural Sciences, University of Jos, Nigeria.
  • E. T. Lengnen Department of Zoology, Faculty of Natural Sciences, University of Jos, Nigeria.
  • N. B. Kamji Department of Zoology, Faculty of Natural Sciences, University of Jos, Nigeria.
  • D. P. Yakubu Department of Zoology, Faculty of Natural Sciences, University of Jos, Nigeria.




Plasmodium berghei, laboratory mice, Curcuma longa extracts, Antiplasmodial activity


Malaria is a leading cause of morbidity and mortality worldwide, especially in developing countries and in sub-Saharan Africa where most malaria cases and deaths occur. The resistance of malaria parasites to most anti-malaria drugs, coupled with the high cost and the toxic effects of some drugs has posed a challenge for the search of new effective anti-malarial compounds of low cost. The study aims to determine the antiplasmodial activity of Curcuma longa against Plasmodium berghei in rodents. A total of 110 Swiss albino mice weighing 18-30 grams were used for the study: 35 for the toxicity test and 75 for the antimalarial study. For each test, 25 mice were inoculated with drug-sensitive Nk65 Plasmodium berghei and divided into five groups of five animals each and each group was administered one of the following: 120mg/kg of ethanol extract, 120mg/kg water extract, 120mg/kg nHexane extracts of C. longa, 1.2mg/kg of pyrimethamine or 5mg/kg of Chloroquine (positive control) and 0.2mls of normal saline (negative control). The lethal dose concentration was above 1500mg/kg and the extracts showed significant (P<0.05) antimalarial activity with the highest percentage inhibition (67.49%) recorded in the group treated with ethanol in the curative test, followed by the group given water in the suppressive test with (65.03%) and nHexane in the prophylactic test with percentage inhibition of 64.98%. There was a slight difference
in the antimalarial activities of the extracts of different solvents which all had lower activities compared with the standard drugs (Chloroquine administered at 5mg/kg or pyrimethamine, 1.2mg/kg/day) but no total clearance of the parasite was recorded. C. longa possesses considerable antiplasmodial activity, which can be exploited in malaria therapy. 


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How to Cite

Dawet, A., Golnaan, C. H., Yusuf, K., Lengnen, E. T., Kamji, N. B., & Yakubu, D. P. (2024). Evaluation of the Antiplasmodial activity of <i>Curcuma longa</i> (turmeric - Zingiberaceae) on <i>Plasmodium berghei</i> in Laboratory Mice. Nigerian Journal of Parasitology, 45(1), 47–56. https://doi.org/10.4314/njpar.v45i1.6

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