Lactose intolerance among under five children with malaria in Port Harcourt, Nigeria
http://dx.doi.org/10.4314/njpar.v40i2.1
Keywords:
Nigeria, under five children, malaria, Lactose IntoleranceAbstract
This study assessed the occurrence of lactose intolerance among children under five years of age with malaria in Port Harcourt, south-southern Nigeria. One hundred and twenty-four (124) under five children attending paediatric clinics in Braithwaite Memorial Specialist Hospital, Port Harcourt, were selected for the study through purposive and systematic random sampling. Blood samples were collected from heel or thumb prick of the children to determine malaria parasite status while stool samples were collected for stool acidity test to determine lactose intolerance in the children. Data was analyzed on SPSS version 20.0. Results show that among the study children, there were more females (56.5%) and mostly those 2 years of age (26.6%) of which 54.8% were nourished. All the children tested positive for malaria with 53.3% having parasite density of 9000-50000 Å–. About 69.4% of these children had acidic stool pH (< 5.5) indicative of lactose intolerance. The study found a significant relationship between malaria parasite density and lactose intolerance (p<0.05). A significant relationship (p<0.05) was also found between nutritional status and lactose intolerance among children with malaria. Malaria infection could predispose to lactose intolerance in children as observed in this study. It is therefore very important that prevention or early diagnosis and treatment of malaria among under-five children should be greatly encouraged to prevent lactose intolerance and its deleterious outcome in children.
References
WHO. 2015. World Malaria Report. Retrieved November 16, 2017, from http://www.who.int/malaria/publications/world-malaria-report-2015/en/
Bartoloni, A. and Zammarchi, L. 2012. Clinical aspects of uncomplicated and severe malaria. Mediterranean
Journal of Hematology and Infectious Diseases, 4(1): e2012026.
Chukwuocha U. M., Osuagwu, A. E., Dozie, I. N. S., Nwoke, B. E., Onwuliri, C. O. and Ukaga, C. N. 2009. The clinical pattern and complications of severe malaria in parts of the Imo River Basin of Nigeria. Nigerian Hospital Practice, 3(6): 76-79.
WHO. 2014. World Malaria Report 2014. Geneva, Switzerland: World Health Organization. Retrieved September 12, 2017 from http://www.who.int/ malaria/publications/world-malaria-report-2014/en/
National Malaria Control Programme. 2009. Strategic plan 200902013: “A roadmap for malaria control in Nigeria”, abridged version. Abuja: Yaliam Press Ltd, Federal Ministry of Health.
Prasad, R. N. and Virk, K. J. 1993. Malaria as a cause of diarrhea – A review. PapuaNew Guinea Medical Journal, 36(4): 337-41.
Caraballo, H. and King K. 2014. Emergency department management of mosquito-borne illness: Malaria, dengue, and West Nile virus. Emergency Medicine Practice, 16(5): 1-23; quiz 23-4.
Campbell, A. K., Waud, J. P.and Matthews, S. B. 2005. The molecular basis of lactose intolerance. Science Progress, 88(3): 157-202.
Tan-Dy, C. R. Y. and Ohlsson A. 2013. Lactase treated feeds to promote growth and feeding tolerance in preterm infants. Cochrane Database of Systematic Reviews, 3. Art. No.: CD004591. DOI: 10.1002/ 14651858.CD004591.pub3.
Mattar, R., Campos, D. Mazo, D. F. and Carrilho, F. J. 2012. Lactose intolerance: Diagnosis, Genetic, and Clinical Factors. Clinical and Experimental Gastroenterology, 3(5): 33-87.
Bartoloni, A. and Zammarchi, L. 2012. Clinical aspects of uncomplicated and severe malaria. Mediterranean
Journal of Hematology and Infectious Diseases, 4 (1): e2012026.
Braithwaite Memorial Specialist Hospital. 2017. Our history. Braithwaite Memorial Specialist Hospital Port Harcourt, Nigeria, Retrieval Date 22/6/2017.
Bagmar, M. S. H. and Khudri M. M. 2015. Tracking changes and identifying determinants of child malnutrition status over the past decade in Bangladesh. Pakistan Journal of Nutrition, 14: 964-971.
Villavieja, G. M., LaÜa, R. D. and CerdeÜa, C. M. 1999. Updating of nutritional status of Filipino children at the provincial level. Philippines 1998. Manila: Food and Nutrition Research Institute FNRI, DOST.
WHO. 2018. Child growth standards. Retrieved on 21/12/2018 from https://www.who.int/childgrowth/standards/technical_report/en/.
Bonheur, J. L. 2017. Bacterial Gastroenteritis: Practice Essential, Background, Etiology. Retrieved March 7, 2018, from https://emedicine.medscape.com.
Brabin, L. 2005. HIV, malaria and beyond: Reducing the disease burden of female adolescents. Malaria Journal, 4: 2.
WHO. 2013. World malaria report, Geneva: Retrieved September 12, 2017, from http://www.who.int/ malaria/publications/world-malaria-report-2013/en/
Jeremiah, Z. A. and Uko, E. K. 2007. Comparative analysis of malaria parasite density using actual and assumed white blood cell counts. Annals of Tropical Pediatrics, 27(1): 9-75.
Stefano, G., Richard, E. F.,Delia, M. R. and Stephen, M. B. 2017. Pediatric Lactose Intolerance. Retrieved on 13 August 2018, from https://emedicine.medscape. com/article/930971-overview.
Harvey, L., Ludwig, T., Hou, A. Q., Hock, Q. S., Tan, M. L. N., Osatakul S., Bindels, J. and Muhardi, L. 2018. Prevalence, cause and diagnosis of lactose intolerance in children aged 1-5 years: a systematic review of 1995-2015 literature. Asia Pacific Journal of Clinical Nutrition, 27(1): 29-46.
Hemmer, C. J., Lehr, H. A., Westphal, K., Unverricht, M., Kratzius, M., and Reisinger, E. C. 2005. Plasmodium falciparum Malaria: Reduction of endothelial cell apoptosis in vitro. Infection and immunity, 73(3): 1764-1770.
McGregor, I. A. 1988. Malaria and Nutrition. In: Malaria: Principles and Practice of Malariology. London. Churchill Livingstone.
Shaukat A., Levitt M. D., Taylor B. C., MacDonald R., Shamliyan T. A., Kane R. L. and Wilt T. J. 2010. Systematic review: Effective management strategies for lactose intolerance. Annals of Internal Medicine, 152(12): 797-803.
Caulfield, L. E., Richard, S. A. and Black, R. E. 2004. Under nutrition as an underlying cause of Malaria Morbidity and Mortality in Children less than five years old. American Journal of Tropical Medicine and Hygiene, 71(2): 55-63.
James, K. R. and Gabriel, A. 2013. The Interaction between Malaria and Nutrition. Retrieved August 12, 2018, from https://www.nestlenutrition-institute.org/ country/za/news/article/2013/10/21/theinteraction-between-malaria-and-nutrition.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Nigerian Journal of Parasitology
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.