In Vitro Assessment of Anti plasmodial Activity of Albizia chevalieri extracts against Plasmodium falciparum
https://dx.doi.org/10.4314/njpar.v43i1.2
Keywords:
parasitaemia, Microtitre plate, Antiplasmodial, Albizia chevalieriAbstract
Medicinal plants play a key role in malaria control in Africa, especially in remote areas where health facilities are limited. This study was carried out with the aim to investigate the anti plasmodial activity of Albizia chevalieri against Plasmodium falciparum. The three aerial parts of Albizia chevalieri were extracted using methanol via maceration process. Anti plasmodial assay was carried out in duplicate in the 96-well microtitre plate. The anti Plasmodial activity of A. chevalieri methanolic extracts observed in this study may be attributed to the presence of some bioactive compounds. The effect of A. chevalieri methanolic extracts and reference drugs showed a decrease in percentage parasitaemia with increasing concentration. With regard to concentrations administered, a dose-dependent antimalarial activity was clearly shown for crude extract, isolates and the reference drugs. Artemether, the root isolate and leaf isolate exhibited a remarkable antiplasmodial activity. Root, leaf extracts and the pure isolates when compared with the standard drug that has the highest percentage inhibition shows no significance difference at (P>0.05). However, when compared with the other drugs such as Chloroquine, Quinine shows a significance percentage inhibition difference at (P>0.05). Considering the inhibitory effect of A. chevalieri methanol extracts on the growth of P. falciparum as reported in this study, it is concluded that the anti plasmodial activity of the plant on P. falciparum suggests its potency in the treatment of malaria infection. Further study on this plant is on-going to isolate, identify and characterize the bioactive compounds from this plant responsible for this bioactivity, and also to carry- out the drug synthesis.
References
Adoum, S., and Coker, H. (2001). Plants used in Traditional Medicine against Malaria. The Nigerian Journal of Pharmacy, 32, 50-63.
Alhassane, B. (2013). Vegetal Biodiversity: Albizia chevalieri. http://ecologistesud.emonsite.com/en/blog/vegetal-biodiversityalbizia-chevalieri.html.
Burkill, H. (1995). The Useful Plants of West Tropical Africa. Families J'L, Royal Botanical Gardens, 3, 207-208.
Bharat, G and Parabia, M. H. (2010). Pharmacognostic evaluation of bark and seeds of MimusopselengiL. International Journal of Pharmacy and Pharmaceutical Sciences, 2: 110-113.
Crammer M.S. (1997). Sudden radiactive braking in colliding hot-star winds. The Astrophysical Journal, 475(2), 786.
Fabricant, D., and Farnsworth, N. (2001). The value of plants used in traditional medicine for drug discovery. Environmental
Health Perspective, 109.
Hajara, S., Samaila, A., Nayaya, A., Danladi, M., Musa, M., Abdulwahab, A., and Nazeef , I. (2017). In vivo screening of Antiplasmodial Activity of Methanolic Leaf Extract of Albizia chevalieri Against Plasmodium berghei Model. Greener Journal of Biological Sciences, 7(4), 034-044.
Jennet-Siems, K., Mockenhaupt, F. P.,Bienzle, U., Gupta, M. P., and Eich, E.(1999). In vitro antiplasmodial activity ofCentral American Medicinal Plants. Tropical Medicine and International Health, 4(9), 611-615.
Molta, N. B., Oguche, S., Pam, S. D., Omalu, N. C., and Gyang, V. P. (2006). Efficacy of a single dose of amodiaquine coadministered with sulfoxine/pyrimethamine combination against falciparum infection in an area of multi-drug resistant malaria in Barikin Ladi, North Central Nigeria. Journal of Pharmacy and Bioresources, 3(1), 1-4.
Mustofa, J., Sholikhah, E., and Waliyuonuo, S. (2007). In vitro and in vivo antiplasmodial activity and cytotoxicity of extracts of Phyllantus niruri L herbs traditionally used to treat malaria in Indonesia. Southeast Asian Journal of Tropical Medicine and Public Health, 38(4), 609-615.
Ngemenya, M.N., Djeukem, G.G.R., Nyongbela, K.D., Bate, P.N.N., Babiaka, S.B., Monya, E., and Kanso, R.K. (2019). Microbial, photochemical, toxicity analyses, and antibacterial activity against multidrug resistant bacteria of some traditional remedies sold in Buea Southwest Cameroon. Complement Alternative medicine. 19(1);150
Palanishwamy and Venkatachalam S.G., (2007). Fontan operation: a comparison of lateral tunnel with extra cardiac conduit. The Annals of Thoracic Surgery, 83(2), 622-30.
Rasoanaivo, P., Ratismamanga-Uverg, S., Milijaona, R., Rafatro, H., Rakoto Ratsimamanga, A., Gallefi, C. and Nicoletti, M. (1994). In vitro and invo chloroquine-potentiating action of strychnos myrtoids alkaloids against chloroquine resistant strains of Plasmodium malaria. Planta medica, 60(1), 13-16.
Quattara, Y., Sanon, S., Traore, Y., Mahiou, V., Azas, N., and Sawadogo, L. (2006). Antimalarial activity Swastzia madagascariensis Desv. (leguminosae), combretum glutinosum Guill and Perr.(combretaceae) and Tinospora bakis Miers.(menispermaceae) Burkina Faso Plants. African Journal of Traditional, Complementary & Alternative Medicine, 3(1), 75-81.
Sofowora, A. (2008). Medicinal Plants and Traditional Medicine in Africa. Spectrum Books Limited, 3rd Edition. Ibadan, Nigeria. Pp 200-202.
Trager, W., and Jensen, J. B. (1976). Human malaria parasites in continuous culture. Science, 193, 673-675.
Taylor, T. (1993). Rapid coma resolution with artemether in Malawian children with cerebral malaria. Lancet, 341(8851), 1035.
Wilcox, H.C., Conner, K.R., and Caine, E.D. (2014).Association of alcohol and drug use disorders and completed suicide: An empirical review of cohort studies. Drug Alcohol Depend. 7;76 suppl: S11-9
WHO. (2001a). The use of antimalarial drugs. Report of a WHO informal consultation. 13–17 November 2000. (WHO/CDS/RBM/2001.33). Geneva: World Health Organization.
WHO (2008). Traditional Medicine. Retrieved from http://www.who.int/mediacentre/factsheets/fs134/en/
WHO (2011). Quality Control Methods for Medicinal Plants. WHO, Geneva, Switzerland. Pp 31. 69
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